Chronic hemolytic anemia associated with thalassemia and sickling traits.

By P5IILLIP STURGEON, M.1)., F1. ntvF Y A. IT No, M.I)., Pmn.1). .ND WII4LIAM N. \ALENTINE, MD. P O\VELL, RO1)ARTE AN1) NEEL’ recemstly desen-ibed ins detail a family of Sicilians amscestrv displayinsg both the sickle cell trait amid thalassemia minor; the first family displayinsg boths of thuese tm-aits d!es(’ribed ins thsis counmstmy. Ins one member of this family exhibit-mug a severe cisronuic hsemolytic anuemia, w’hicls w’as climsically imsdistimsgunishable from sickle (‘eli amsemia, boths traits ss’ere presenst. Ins this paper attemstions w’as also tlirectec! to thse reports from Italy by Silvestronsi amid Bianuco2 of five families exhibitinsg the same phensomemsons. In the counrse of thse study ims this climsic of a case of chsromsic hemolytic ansemia ins 6 year old girl of Italians amid Mexicans anscestry a similan family was discovered. This represensts the seconsd family of this nsatunre recogmsized irs the Umsited States. The purpose of this report is (1) to describe this chromsic hsemolytic amsemia as it was observed in a child, (2) to presenut data which fusrther characterize the amsemia and (3) to dlescribe the unmsiqume electrophoretic patterns of this patiemit’s hsemoglohin.